2-(4-Chloro-butyl)-2H-[1,2,4]triazine-3,5-dione → 2-{4-[4-(2-tert-Butyl-6-propyl-pyrimidin-4-yl)-piperazin-1-yl]butyl}-2H-[1,2,4]triazine-3,5-dione

HRID 453649노트

반응식

HRID 453649 반응식
Cl[CH2:2][CH2:3][CH2:4][CH2:5][N:6]1[C:11](=[O:12])[NH:10][C:9](=[O:13])[CH:8]=[N:7]1.[C:14]([C:18]1[N:23]=[C:22]([N:24]2[CH2:29][CH2:28][NH:27][CH2:26][CH2:25]2)[CH:21]=[C:20]([CH2:30][CH2:31][CH3:32])[N:19]=1)([CH3:17])([CH3:16])[CH3:15]>>[C:14]([C:18]1[N:23]=[C:22]([N:24]2[CH2:29][CH2:28][N:27]([CH2:2][CH2:3][CH2:4][CH2:5][N:6]3[C:11](=[O:12])[NH:10][C:9](=[O:13])[CH:8]=[N:7]3)[CH2:26][CH2:25]2)[CH:21]=[C:20]([CH2:30][CH2:31][CH3:32])[N:19]=1)([CH3:17])([CH3:16])[CH3:15]

참가 물질

3

반응물 2

HCID 158171752-(4-Chloro-butyl)-2H-[1,2,4]triazine-3,5-dioneHCID 22349857HCID 22349857, 화합물

생성물 1

HCID 426033732-{4-[4-(2-tert-Butyl-6-propyl-pyrimidin-4-yl)-piperazin-1-yl]butyl}-2H-[1,2,4]triazine-3,5-dione

실험 절차

2-{4-[4-(2-tert-Butyl-6-propyl-pyrimidin-4-yl)-piperazin-1-yl]butyl}-2H-[1,2,4]triazine-3,5-dione was prepared from 2-(4-chloro-butyl)-2H-[1,2,4]triazine-3,5-dione and 2-tert-butyl-4-piperazin-1-yl-6-propylpyrimidine by analogy to the process described in example 1.

출처 및 근거

ORD 기록
ord-76a4c537c98744ffb94b79ca6a7c0a28
출처 데이터셋
uspto-grants-2013_07
특허 번호
US08492540B2

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