4-Fluorobenzyl chloride → 5-(4-Fluoro-benzyloxy)-2-nitro-meta-xylene

HRID 453940

반응식

HRID 453940 반응식
[CH3:1][C:2]1[CH:3]=[C:4]([OH:12])[CH:5]=[C:6]([CH3:11])[C:7]=1[N+:8]([O-:10])=[O:9].[F:13][C:14]1[CH:21]=[CH:20][C:17]([CH2:18]Cl)=[CH:16][CH:15]=1.C(=O)([O-])[O-].[K+].[K+]>CC(C)=O>[F:13][C:14]1[CH:21]=[CH:20][C:17]([CH2:18][O:12][C:4]2[CH:5]=[C:6]([CH3:11])[C:7]([N+:8]([O-:10])=[O:9])=[C:2]([CH3:1])[CH:3]=2)=[CH:16][CH:15]=1

참가 물질

5

반응물 3

HCID 96024-Fluorobenzyl chlorideHCID 11430Potassium CarbonateHCID 1384663,5-Dimethyl-4-nitrophenol

생성물 1

HCID 670834645-(4-Fluoro-benzyloxy)-2-nitro-meta-xylene

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

A mixture of 3,5-dimethyl-4-nitrophenol (0.97 g, 5.79 mmol), 4-fluorobenzyl chloride (1.26 g, 8.69 mmol) and anhydrous potassium carbonate (1.24 g, 9.0 mmol) in 50 ml of acetone was stirred under reflux for 22 hours. TLC showed this reaction is complete. The reaction mixture was cooled to room temperature and filtered and washed with acetone. The filtrate was evaporated to dryness to give the crude product, which was used for next step without further purification.

후처리

  1. temperatureunder reflux for 22 hours
  2. filtrationfiltered
  3. washwashed with acetone
  4. customThe filtrate was evaporated to dryness

출처 및 근거

ORD 기록
ord-a6ac003ef0014afa89d6ce38f6a7d273
출처 데이터셋
uspto-grants-2013_07
특허 번호
US08492588B2

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