7-Benzyloxy-6-methoxy-4-phenoxyquinazoline → 7-Hydroxy-6-methoxy-4-phenoxyquinazoline

HRID 453983노트

반응식

HRID 453983 반응식
C([O:8][C:9]1[CH:18]=[C:17]2[C:12]([C:13]([O:19][C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)=[N:14][CH:15]=[N:16]2)=[CH:11][C:10]=1[O:26][CH3:27])C1C=CC=CC=1>C(O)(C(F)(F)F)=O>[OH:8][C:9]1[CH:18]=[C:17]2[C:12]([C:13]([O:19][C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)=[N:14][CH:15]=[N:16]2)=[CH:11][C:10]=1[O:26][CH3:27]

참가 물질

3

반응물 1

HCID 218748147-Benzyloxy-6-methoxy-4-phenoxyquinazoline

생성물 1

HCID 1354961377-Hydroxy-6-methoxy-4-phenoxyquinazoline수율 96%

시약·촉매·용매 1

HCID 6422Trifluoroacetic acid용매

실험 절차

7-Benzyloxy-6-methoxy-4-phenoxyquinazoline (36.95 g, 105.5 mmol) was suspended in TFA (420 ml) and heated at reflux for 3 hours. The reaction mixture was allowed to cool and evaporated under vacuum. The residue was stirred mechanically in water then basified with saturated aqueous sodium hydrogen carbonate solution and stirred overnight. The water was decanted and the solid suspended in acetone. After stirring the white solid was collected by filtration, washed with acetone and dried to give 7-hydroxy-6-methoxy-4-phenoxyquinazoline (26.61 g, 96%).

후처리

  1. temperatureheated
  2. temperatureat reflux for 3 hours
  3. temperatureto cool
  4. customevaporated under vacuum
  5. stirringstirred overnight
  6. customThe water was decanted
  7. stirringAfter stirring the white solid
  8. filtrationwas collected by filtration
  9. washwashed with acetone
  10. customdried

출처 및 근거

ORD 기록
ord-3b2faee5f001413abb79fc6904f74e69
출처 데이터셋
uspto-grants-2013_07
특허 번호
US08492560B2

반응 노트

불러오는 중…