Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2,2,4-Trimethyl-1,2-dihydro-6-quinolinol → HCID 22030881, 화합물
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2,2,4-Trimethyl-1,2-dihydro-6-quinolinol | HCID 599799 | — |
| 반응물 | 4-Chloro-6-methoxy-7-(3-pyrrolidin-1-ylpropoxy)quinazoline | HCID 11141792 | — |
| 생성물 | HCID 22030881 | HCID 22030881 | 47% |
반응 단계
Using a procedure analogous to that described for Example 9, 4-chloro-6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy)quinazoline (0.13 g, 0.4 mol), (prepared as described for the starting material in Example 9), was reacted with 2,2,4-trimethyl-1,2-dihydroquinolin-6-ol (95 mg, 0.5 mmol), (IZV. ACAD. NAVK. SSSR. Ser. Khim. 1981, 9, 2008), to give 6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy)-4-(2,2,4-trimethyl-1,2-dihydroquinolin-6-yloxy)quinazoline (90 mg, 47%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08492560B2 |
| 출처 데이터셋 | uspto-grants-2013_07 |
| ORD ID | ord-3d79816d5ea14443842574dfe77a355c |
| 출처 메모 | uspto-grants-2013_07 |