Triethylamine → 3-Fluoro-7-methoxyquinoline
반응식
Cl[C:2]1[C:11]([F:12])=[CH:10][C:9]2[C:4](=[CH:5][C:6]([O:13][CH3:14])=[CH:7][CH:8]=2)[N:3]=1.C(N(CC)CC)C>[Pd].C(O)C>[F:12][C:11]1[CH:2]=[N:3][C:4]2[C:9]([CH:10]=1)=[CH:8][CH:7]=[C:6]([O:13][CH3:14])[CH:5]=2참가 물질
5
실험 절차
A mixture of 2-chloro-3-fluoro-7-methoxyquinoline (310 mg, 1.47 mmol), triethylamine (310 mg, 0.4 ml, 3.07 mmol) and 10% palladium on activated charcoal (50 mg) in dry ethanol (5 ml) was stirred under hydrogen gas at ambient temperature for 24 hours. The mixture was then filtered through celite. The celite was washed with methanol and the solvent was removed by evaporation from the combined filtrates. The crude material was purified by chromatography on silica, eluting with 10% ethyl acetate in isohexane to give 3-fluoro-7-methoxyquinoline (130 mg, 54%).
후처리
- filtrationThe mixture was then filtered through celite
- washThe celite was washed with methanol
- customthe solvent was removed by evaporation from the combined filtrates
- customThe crude material was purified by chromatography on silica
- washeluting with 10% ethyl acetate in isohexane
출처 및 근거
- ORD 기록
- ord-73022471c3ff43c886d326df070c7eaf
- 출처 데이터셋
- uspto-grants-2013_07
- 특허 번호
- US08492560B2
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