5-Benzyloxy-6-methoxyindole → 6-Methoxy-1H-indol-5-ol

HRID 454151노트

반응식

HRID 454151 반응식
C([O:8][C:9]1[CH:10]=[C:11]2[C:15](=[CH:16][C:17]=1[O:18][CH3:19])[NH:14][CH:13]=[CH:12]2)C1C=CC=CC=1>CO.[Pd]>[OH:8][C:9]1[CH:10]=[C:11]2[C:15](=[CH:16][C:17]=1[O:18][CH3:19])[NH:14][CH:13]=[CH:12]2

참가 물질

4

반응물 1

HCID 2608005-Benzyloxy-6-methoxyindole

생성물 1

HCID 1649576-Methoxy-1H-indol-5-ol수율 87%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

5-Benzyloxy-6-methoxyindole (253 mg, 1.0 mmol) was hydrogenated at 1 atmosphere pressure in methanol (10 ml) with 10% palladium on carbon (50 mg) for 2 hours at 25° C. The catalyst was filtered off and the filtrate evaporated to give 5-hydroxy-6-methoxylindole (141 mg, 87%).

후처리

  1. filtrationThe catalyst was filtered off
  2. customthe filtrate evaporated

출처 및 근거

ORD 기록
ord-6dfaa82a21cc4575987b571cae707983
출처 데이터셋
uspto-grants-2013_07
특허 번호
US08492560B2

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