Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2-Methyl-5-nitro-1H-indole → 5-Amino-2-methylindole
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2-Methyl-5-nitro-1H-indole | HCID 280313 | — |
| 반응물 | HCID 178418361 | HCID 178418361 | — |
| 촉매 | Palladium | HCID 23938 | — |
| 용매 | Ethanol | HCID 702 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | 5-Amino-2-methylindole | HCID 2733992 | 99.6% |
반응 단계
A solution of 2-methyl-5-nitroindole (1 g, 5.7 mmol) in ethanol (25 ml) and THF (25 ml) containg 10% palladium on charcoal (128 mg) was hydrogenated until uptake of hydrogen ceased. The mixture was filtered and the filtrate was evaporated to give 5-amino-2-methylindole (830 mg, quant.).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08492560B2 |
| 출처 데이터셋 | uspto-grants-2013_07 |
| ORD ID | ord-fa041f888df349298ff5b641bf002f5e |
| 출처 메모 | uspto-grants-2013_07 |