Nitric Acid → HCID 22030612, 화합물

HRID 454309

반응식

HRID 454309 반응식
C[O:2][C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][CH:11]=1)[NH:8][C:7]([C:12]([O:14][CH2:15][CH3:16])=[O:13])=[CH:6]2.[N+:17]([O-])([OH:19])=[O:18]>ClCCl>[OH:2][C:3]1[C:4]([N+:17]([O-:19])=[O:18])=[C:5]2[C:9](=[CH:10][CH:11]=1)[NH:8][C:7]([C:12]([O:14][CH2:15][CH3:16])=[O:13])=[CH:6]2

참가 물질

4

반응물 2

HCID 944Nitric AcidHCID 20926Ethyl 5-methoxyindole-2-carboxylate

생성물 1

HCID 22030612HCID 22030612, 화합물수율 59%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

A mixture of ethyl 5-methoxyindole-2-carboxylate (8.15 g, 37.2 mmol), (prepared by the method described in Heterocycles Vol. 43, No. 2, p. 263-266), nitric acid adsorbed on silica gel (24 g) and dichloromethane (150 ml) was stirred at ambient temperature for 18 hours. The dichloromethane was removed in vacuo and the product washed off the silica with acetone. The acetone was evaporated in vacuo. The residue was treated again with nitric acid on silica (1 g) as above and the work up procedure repeated to give ethyl 5-hydroxy-4-nitroindole-2-carboxylate (5.8 g, 59%).

후처리

  1. custom(prepared by the method
  2. customThe dichloromethane was removed in vacuo
  3. washthe product washed off the silica with acetone
  4. customThe acetone was evaporated in vacuo
  5. additionThe residue was treated again with nitric acid on silica (1 g) as above and the work up procedure

출처 및 근거

ORD 기록
ord-132ad3e4bce44edb80e78c38a37e2a70
출처 데이터셋
uspto-grants-2013_07
특허 번호
US08492560B2

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