Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
3-Isopropyl-4-methyl-1-pentyn-3-ol → 2,2,2-trifluoro-N-(3-(3-(3-hydroxy-3-isopropyl-4-methylpent-1-ynyl)phenyl)propyl)acetamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 3-Isopropyl-4-methyl-1-pentyn-3-ol | HCID 220090 | — |
| 반응물 | N-(3-(3-bromophenyl)propyl)-2,2,2-trifluoroacetamide | HCID 57608389 | — |
| 생성물 | 2,2,2-trifluoro-N-(3-(3-(3-hydroxy-3-isopropyl-4-methylpent-1-ynyl)phenyl)propyl)acetamide | HCID 86628452 | — |
반응 단계
Coupling of 3-isopropyl-4-methylpent-1-yn-3-ol with bromide 3 following the coupling method described in Example 17 gave 2,2,2-trifluoro-N-(3-(3-(3-hydroxy-3-isopropyl-4-methylpent-1-ynyl)phenyl)propyl)acetamide as a pale yellow oil. Yield (1.375 g, 66%): 1H NMR (400 MHz, DMSO-d6) δ 9.40 (br s, 1H), 7.26 (t, J=7.6 Hz, 1H), 7.17-7.22 (m, 3H), 4.81 (s, 1H), 3.17 (q, J=6.8 Hz, 2H), 2.56 (t, J=8.0 Hz, 2H), 1.86 (quint, J=6.8 Hz, 2H), 1.76 (quint, J=7.6 Hz, 2H), 0.99 (d, J=6.8 Hz, 6H), 0.94 (d, J=6.8 Hz, 6H).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08492589B2 |
| 출처 데이터셋 | uspto-grants-2013_07 |
| ORD ID | ord-64598c95e9fc42ebaa998fd59384caa6 |
| 출처 메모 | uspto-grants-2013_07 |