Trifluoroacetic acid → 2-(2-Hydroxy-5-phenylbenzamido)-4-phenylbenzoic acid

HRID 454581노트

반응식

HRID 454581 반응식
FC(F)(F)C(O)=O.[OH:8][C:9]1[CH:36]=[CH:35][C:34]([C:37]2[CH:42]=[CH:41][CH:40]=[CH:39][CH:38]=2)=[CH:33][C:10]=1[C:11]([NH:13][C:14]1[CH:26]=[C:25]([C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=2)[CH:24]=[CH:23][C:15]=1[C:16]([O:18]C(C)(C)C)=[O:17])=[O:12]>C(Cl)Cl>[OH:8][C:9]1[CH:36]=[CH:35][C:34]([C:37]2[CH:42]=[CH:41][CH:40]=[CH:39][CH:38]=2)=[CH:33][C:10]=1[C:11]([NH:13][C:14]1[CH:26]=[C:25]([C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=2)[CH:24]=[CH:23][C:15]=1[C:16]([OH:18])=[O:17])=[O:12]

참가 물질

4

반응물 2

HCID 6422Trifluoroacetic acidHCID 58508748Tert-butyl 2-(2-hydroxy-5-phenylbenzamido)-4-phenylbenzoate

생성물 1

HCID 468536212-(2-Hydroxy-5-phenylbenzamido)-4-phenylbenzoic acid수율 96.3%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

Trifluoroacetic acid (1 mL) was added to a methylene chloride (3 mL) solution of the obtained tert-butyl 2-(2-hydroxy-5-phenylbenzamido)-4-phenylbenzoate (0.085 g), followed by stirring at room temperature for 17 hours. The solvent was evaporated under reduced pressure, and ethyl acetate was added to the residue. The solid substance was collected by filtration to obtain 0.072 g of 2-(2-hydroxy-5-phenylbenzamido)-4-phenylbenzoic acid as a white solid.

후처리

  1. customThe solvent was evaporated under reduced pressure, and ethyl acetate
  2. additionwas added to the residue
  3. filtrationThe solid substance was collected by filtration

출처 및 근거

ORD 기록
ord-5ea47a02dab145319251d3c9841217d9
출처 데이터셋
uspto-grants-2013_07
특허 번호
US08492582B2

반응 노트

불러오는 중…