Trifluoroacetic acid → 2-(5-(Furan-3-yl)-2-hydroxybenzamido)-4-phenylbenzoic acid

반응식

C1(SC)C=CC=CC=1.FC(F)(F)C(O)=O.C([O:23][C:24]1[CH:51]=[CH:50][C:49]([C:52]2[CH:56]=[CH:55][O:54][CH:53]=2)=[CH:48][C:25]=1[C:26]([NH:28][C:29]1[CH:41]=[C:40]([C:42]2[CH:47]=[CH:46][CH:45]=[CH:44][CH:43]=2)[CH:39]=[CH:38][C:30]=1[C:31]([O:33]C(C)(C)C)=[O:32])=[O:27])C1C=CC=CC=1>>[O:54]1[CH:55]=[CH:56][C:52]([C:49]2[CH:50]=[CH:51][C:24]([OH:23])=[C:25]([CH:48]=2)[C:26]([NH:28][C:29]2[CH:41]=[C:40]([C:42]3[CH:47]=[CH:46][CH:45]=[CH:44][CH:43]=3)[CH:39]=[CH:38][C:30]=2[C:31]([OH:33])=[O:32])=[O:27])=[CH:53]1

참가 물질

반응물 3

HCID 6422Trifluoroacetic acid

HCID 7520Thioanisole

HCID 66990487Tert-butyl 2-(2-(benzyloxy)-5-(furan-3-yl)benzamido)-4-phenylbenzoate

생성물 1

HCID 585089272-(5-(Furan-3-yl)-2-hydroxybenzamido)-4-phenylbenzoic acid수율 19.5%

실험 절차

Thioanisole (1.6 mL) and trifluoroacetic acid (5.2 mL) were added to tert-butyl 2-(2-(benzyloxy)-5-(furan-3-yl)benzamido)-4-phenylbenzoate (0.14 g), followed by stirring at room temperature for 4 hours. The solvent was evaporated under reduced pressure, and dioxane was added to the residue. The solvent was evaporated under reduced pressure, and ethyl acetate was added to the residue. The solid substance was collected by filtration to obtain 0.020 g of 2-(5-(furan-3-yl)-2-hydroxybenzamido)-4-phenylbenzoic acid as a white solid.