Trifluoroacetic acid → 4-Phenyl-2-(6-phenylpyridine-3-carboxamido)benzoic acid

HRID 454732노트

반응식

HRID 454732 반응식
FC(F)(F)C(O)=O.[C:8]1([C:14]2[CH:26]=[CH:25][C:17]([C:18]([O:20]C(C)(C)C)=[O:19])=[C:16]([NH:27][C:28]([C:30]3[CH:31]=[N:32][C:33]([C:36]4[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=4)=[CH:34][CH:35]=3)=[O:29])[CH:15]=2)[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1>>[C:8]1([C:14]2[CH:26]=[CH:25][C:17]([C:18]([OH:20])=[O:19])=[C:16]([NH:27][C:28]([C:30]3[CH:31]=[N:32][C:33]([C:36]4[CH:37]=[CH:38][CH:39]=[CH:40][CH:41]=4)=[CH:34][CH:35]=3)=[O:29])[CH:15]=2)[CH:9]=[CH:10][CH:11]=[CH:12][CH:13]=1

참가 물질

3

반응물 2

HCID 6422Trifluoroacetic acidHCID 58508784Tert-butyl 4-phenyl-2-(6-phenylpyridine-3-carboxamido)benzoate

생성물 1

HCID 585086024-Phenyl-2-(6-phenylpyridine-3-carboxamido)benzoic acid

실험 절차

Trifluoroacetic acid (5 mL) was added to the obtained tert-butyl 4-phenyl-2-(6-phenylpyridine-3-carboxamido)benzoate, followed by stirring at room temperature for 3 hours. The solvent was evaporated under reduced pressure, and methanol was added to the obtained residue. The solid substance was collected by filtration to obtain 53 mg of 4-phenyl-2-(6-phenylpyridine-3-carboxamido)benzoic acid as a light yellow solid.

후처리

  1. customThe solvent was evaporated under reduced pressure, and methanol
  2. additionwas added to the obtained residue
  3. filtrationThe solid substance was collected by filtration

출처 및 근거

ORD 기록
ord-7de150240329499c82a64376f700eb42
출처 데이터셋
uspto-grants-2013_07
특허 번호
US08492582B2

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