Trifluoroacetic acid → HCID 58508471, 화합물

HRID 454772노트

반응식

HRID 454772 반응식
FC(F)(F)C(O)=O.C(OC([O:15][C:16]1[CH:17]=[C:18]([C:22]2[CH:34]=[CH:33][C:25]([C:26]([O:28]C(C)(C)C)=[O:27])=[C:24]([NH:35][C:36]([C:38]3[CH:39]=[N:40][CH:41]=[C:42]([C:44]4[CH:49]=[CH:48][CH:47]=[CH:46][CH:45]=4)[CH:43]=3)=[O:37])[CH:23]=2)[CH:19]=[CH:20][CH:21]=1)=O)(C)(C)C>>[OH:15][C:16]1[CH:17]=[C:18]([C:22]2[CH:34]=[CH:33][C:25]([C:26]([OH:28])=[O:27])=[C:24]([NH:35][C:36]([C:38]3[CH:39]=[N:40][CH:41]=[C:42]([C:44]4[CH:45]=[CH:46][CH:47]=[CH:48][CH:49]=4)[CH:43]=3)=[O:37])[CH:23]=2)[CH:19]=[CH:20][CH:21]=1

참가 물질

3

반응물 2

HCID 6422Trifluoroacetic acidHCID 66990697HCID 66990697, 화합물

생성물 1

HCID 58508471HCID 58508471, 화합물

실험 절차

Trifluoroacetic acid (4.0 mL) was added to the obtained tert-butyl 4-(3-(tert-butoxycarbonyl)oxyphenyl)-2-(5-phenylpyridine-3-carboxamido)benzoate, followed by stirring at room temperature for 1 hour and 15 minutes. The solvent was evaporated under reduced pressure, and diisopropyl ether was added to the obtained residue. The solid substance was collected by filtration to obtain 70 mg of 4-(3-hydroxyphenyl)-2-(5-phenylpyridine-3-carboxamido)benzoic acid as a light yellow solid.

후처리

  1. customThe solvent was evaporated under reduced pressure, and diisopropyl ether
  2. additionwas added to the obtained residue
  3. filtrationThe solid substance was collected by filtration

출처 및 근거

ORD 기록
ord-080ecd2a5055458aa60e11edab428afc
출처 데이터셋
uspto-grants-2013_07
특허 번호
US08492582B2

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