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Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 454814생성일: 2026년 10월 25일

Dimethylamine methanol → 2-[2-(N,N-dimethylamino)pyrimidine-4-yl]-6-(2-fluoroethoxy)benzothiophene

https://huagongshe.com/reaction/454814

반응식

참여 물질

역할이름HCID투입량
반응물Dimethylamine methanolHCID 22497844—
반응물2-(2-Chloropyrimidine-4-yl)-6-(2-fluoroethoxy)benzothiopheneHCID 86646556—
생성물2-[2-(N,N-dimethylamino)pyrimidine-4-yl]-6-(2-fluoroethoxy)benzothiopheneHCID 4694772693.3%

반응 단계

2-[2-(N,N-Dimethylamino)pyrimidine-4-yl]-6-(2-fluoroethoxy)benzothiophene (1-36, 77 mg, 93%) was prepared in the same manner as in Example 35 as a yellow solid using 2-(2-chloropyrimidine-4-yl)-6-(2-fluoroethoxy)benzothiophene (105b, 80 mg, 0.26 mmol) obtained in Preparation Example 20 and a 2.0 M dimethylamine methanol solution (NHMe2 in MeOH, 0.26 mL, 0.52 mmol).

출처 및 근거

DOI10.6084/m9.figshare.5104873.v1
특허 번호US08497260B2
출처 데이터셋uspto-grants-2013_07
ORD IDord-96170d9aa23544a8a1f48cc3111b62dc
출처 메모uspto-grants-2013_07