Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Sodium methanolate methanol → 2-(2-Methoxypyrimidine-4-yl)-6-(3-fluoropropoxy)benzothiophene
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Sodium methanolate methanol | HCID 23694274 | — |
| 반응물 | 2-(2-Chloropyrimidine-4-yl)-6-(3-fluoropropoxy)benzothiophene | HCID 86646557 | — |
| 생성물 | 2-(2-Methoxypyrimidine-4-yl)-6-(3-fluoropropoxy)benzothiophene | HCID 46947727 | 107.1% |
반응 단계
2-(2-Methoxypyrimidine-4-yl)-6-(3-fluoropropoxy)benzothiophene (1-37, 75 mg, 99%) was prepared in the same manner as in Example 34 as a yellow solid using 2-(2-chloropyrimidine-4-yl)-6-(3-fluoropropoxy)benzothiophene (105c, 70 mg, 0.22 mmol) obtained in Preparation Example 21 and a 0.5 M sodium methoxide methanol solution (0.66 mL, 0.33 mmol).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08497260B2 |
| 출처 데이터셋 | uspto-grants-2013_07 |
| ORD ID | ord-c8fc7ab694bd43689ca6f6e6ee919af6 |
| 출처 메모 | uspto-grants-2013_07 |