Indazolinone → 2-((2-(4-chlorophenyl)imidazo[1,2-a]pyridin-3-yl)methyl)-1H-indazol-3(2H)-one

HRID 455060

반응식

HRID 455060 반응식
Cl.Cl[CH2:3][C:4]1[N:8]2[CH:9]=[CH:10][CH:11]=[CH:12][C:7]2=[N:6][C:5]=1[C:13]1[CH:18]=[CH:17][C:16]([Cl:19])=[CH:15][CH:14]=1.[NH:20]1[C:28]2[C:23](=[CH:24][CH:25]=[CH:26][CH:27]=2)[C:22](=[O:29])[NH:21]1>>[Cl:19][C:16]1[CH:17]=[CH:18][C:13]([C:5]2[N:6]=[C:7]3[CH:12]=[CH:11][CH:10]=[CH:9][N:8]3[C:4]=2[CH2:3][N:21]2[C:22](=[O:29])[C:23]3[C:28](=[CH:27][CH:26]=[CH:25][CH:24]=3)[NH:20]2)=[CH:14][CH:15]=1

참가 물질

3

반응물 2

HCID 81829IndazolinoneHCID 670287193-(Chloromethyl)-2-(4-chlorophenyl)imidazo[1,2-a]pyridine hydrochloride

생성물 1

HCID 670286182-((2-(4-chlorophenyl)imidazo[1,2-a]pyridin-3-yl)methyl)-1H-indazol-3(2H)-one

실험 절차

The title compound was prepared according to Method B and the experimentals described for compound 91 from 3-(chloromethyl)-2-(4-chlorophenyl)imidazo[1,2-a]pyridine hydrochloride and 1H-indazol-3(2H)-one. M/e+ 375 for C21H16ClN4O (M+H)+; 1H-NMR (400 MHz, CDCl3) δ 11.11 (bs, 1H), 8.16 (d, J=6.9 Hz, 1H), 8.01 (d, J=7.7 Hz, 1H), 7.64 (m, 1H), 7.55 (d, J=8.4 Hz, 2H), 7.50 (d, J=8.4 Hz, 1H), 7.30 (t, J=7.3 Hz, 1H), 7.15 (d, J=8.4 Hz, 2H), 6.75 (t, J=7.7 Hz, 1H), 6.60 (t, J=7.7 Hz, 1H), 6.27 (d, J=8.4 Hz, 1H), 5.34 (s, 2H) ppm.

출처 및 근거

ORD 기록
ord-4b6093ccec3441728149258868c60d90
출처 데이터셋
uspto-grants-2013_07
특허 번호
US08497278B2

연결된 노트

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