1-Methyl-3-pyrrolidinol, (+)- → (S)-N-((6-chloro-2-(4-fluorophenyl)imidazo[1,2-a]pyridin-3-yl)methyl)-4-(1-methylpyrrolidin-3-yloxy)pyrimidin-2-amine

HRID 455105

반응식

HRID 455105 반응식
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[N:6]([C:8]([CH2:18][NH:19][C:20]3[N:25]=[C:24]([O:26][C@@H:27]4[CH2:31][CH2:30][N:29]([CH3:32])[CH2:28]4)[CH:23]=[CH:22][N:21]=3)=[C:9]([C:11]3[CH:16]=[CH:15][C:14]([F:17])=[CH:13][CH:12]=3)[N:10]=2)[CH:7]=1.ClC1C=CN=C(NCC2N3C=C(Cl)C=CC3=NC=2C2C=CC(F)=CC=2)N=1.CN1CC[C@H](O)C1>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[N:6]([C:8]([CH2:18][NH:19][C:20]3[N:25]=[C:24]([O:26][C@H:27]4[CH2:31][CH2:30][N:29]([CH3:32])[CH2:28]4)[CH:23]=[CH:22][N:21]=3)=[C:9]([C:11]3[CH:12]=[CH:13][C:14]([F:17])=[CH:15][CH:16]=3)[N:10]=2)[CH:7]=1

참가 물질

4

반응물 3

HCID 6435041-Methyl-3-pyrrolidinol, (+)-HCID 58337026(R)-N-((6-chloro-2-(4-fluorophenyl)imidazo[1,2-a]pyridin-3-yl)methyl)-4-(1-methylpyrrolidin-3-yloxy)pyrimidin-2-amineHCID 583370824-chloro-N-((6-chloro-2-(4-fluorophenyl)imidazo[1,2-a]pyridin-3-yl)methyl)pyrimidin-2-amine

생성물 1

HCID 67029118(S)-N-((6-chloro-2-(4-fluorophenyl)imidazo[1,2-a]pyridin-3-yl)methyl)-4-(1-methylpyrrolidin-3-yloxy)pyrimidin-2-amine

실험 절차

The title compound was prepared in the same fashion as that described for compound 183 from 4-chloro-N-((6-chloro-2-(4-fluorophenyl)imidazo[1,2-a]pyridin-3-yl)methyl)pyrimidin-2-amine and (S)-1-methylpyrrolidin-3-ol. 1H-NMR (CDCl3, 400 MHz, δ) 8.20 (s, 1H), 7.65 (m, 1H), 7.50 (d, J=9.5 Hz, 1H), 9.10 (m, 3H), 5.93 (s, 1H), 5.34 (s, 1H), 4.93 (d, J=4.9 Hz, 2H), 2.75 (m, 4H), 2.33 (s, 3H), 2.25 (m, 2H), 1.95 (m, 1H) ppm; m/e 453 (M+H)+.

출처 및 근거

ORD 기록
ord-bd0dac0333784838813c04eaf53436c9
출처 데이터셋
uspto-grants-2013_07
특허 번호
US08497278B2

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