Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4-Hydroxypyrrolidine → 2-(4-Chlorophenyl)-3-((6-(pyrrolidin-3-yloxy)pyrazin-2-yl)methyl)imidazo[1,2-a]pyridine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4-Hydroxypyrrolidine | HCID 98210 | — |
| 반응물 | (R)-N-((6-chloro-2-(4-fluorophenyl)imidazo[1,2-a]pyridin-3-yl)methyl)-4-(1-methylpyrrolidin-3-yloxy)pyrimidin-2-amine | HCID 58337026 | — |
| 반응물 | 2-(4-Chlorophenyl)-3-((6-chloropyrazin-2-yl)methyl)imidazo[1,2-a]pyridine | HCID 86655124 | — |
| 생성물 | 2-(4-Chlorophenyl)-3-((6-(pyrrolidin-3-yloxy)pyrazin-2-yl)methyl)imidazo[1,2-a]pyridine | HCID 67027734 | — |
반응 단계
The title compound was prepared according to the experimental for compound 183 from 2-(4-chlorophenyl)-3-((6-chloropyrazin-2-yl)methyl)imidazo[1,2-a]pyridine and pyrrolidin-3-ol. M/e+ 406 for C22H21ClN5O (M+H)−; 1H-NMR (400 MHz, CDCl3) δ 8.20 (d, J=6.9 Hz, 1H), 7.91 (dd, J=6.6, 1.8 Hz, 2H), 7.75 (d, J=8.4 Hz, 2H), 7.62 (d, J=9.1 Hz, 1H), 7.42 (d, J=8.4 Hz, 2H), 7.20 (m, 1H), 6.79 (td, J=6.9, 1.1 Hz, 1H), 4.59 (s, 1H), 4.35 (s, 2H), 3.54 (m, 3H), 2.09 (m, 2H), 1.55 (s, 1H) ppm
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08497278B2 |
| 출처 데이터셋 | uspto-grants-2013_07 |
| ORD ID | ord-c0f9f29fcfc340fd9ea7eb6b8d918f96 |
| 출처 메모 | uspto-grants-2013_07 |