1-Vinyl-1,2,4-triazole → 6-fluoro-2-(4-fluorophenyl)-3-((1-vinyl-1H-1,2,4-triazol-5-yl)methyl)imidazo[1,2-a]pyridine

HRID 455128

반응식

HRID 455128 반응식
[F:1][C:2]1[CH:3]=[CH:4][C:5]2[N:6]([C:8]([CH2:18][C:19]3[N:20]([CH3:24])[CH:21]=[CH:22][N:23]=3)=[C:9]([C:11]3[CH:16]=[CH:15][C:14]([F:17])=[CH:13][CH:12]=3)[N:10]=2)[CH:7]=1.FC1C=CC2[N:30](C(C=O)=C(C3C=CC(F)=CC=3)N=2)C=1.C(N1C=NC=N1)=C>>[F:1][C:2]1[CH:3]=[CH:4][C:5]2[N:6]([C:8]([CH2:18][C:19]3[N:23]([CH:22]=[CH2:21])[N:30]=[CH:24][N:20]=3)=[C:9]([C:11]3[CH:16]=[CH:15][C:14]([F:17])=[CH:13][CH:12]=3)[N:10]=2)[CH:7]=1

참가 물질

4

반응물 3

HCID 5652611-Vinyl-1,2,4-triazoleHCID 670290646-fluoro-2-(4-fluorophenyl)-3-((1-methyl-1H-imidazol-2-yl)methyl)imidazo[1,2-a]pyridineHCID 730129166-Fluoro-2-(4-fluorophenyl)imidazo(1,2-a)pyridine-3-carbaldehyde

생성물 1

HCID 670288936-fluoro-2-(4-fluorophenyl)-3-((1-vinyl-1H-1,2,4-triazol-5-yl)methyl)imidazo[1,2-a]pyridine

실험 절차

The title compound was prepared according to Method C and the experimentals described for compound 199 from 6-fluoro-2-(4-fluorophenyl)imidazo[1,2-a]pyridine-3-carbaldehyde and 1-vinyl-1H-1,2,4-triazole. (55 mg, 36%). m/e+=338 (M+H+).

출처 및 근거

ORD 기록
ord-a8d3eb28aa5d4bd0ad0758d6a953e8da
출처 데이터셋
uspto-grants-2013_07
특허 번호
US08497278B2

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