Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Methylamine → 4-chloro-N-methylbutane-1-sulfonamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Methylamine | HCID 6329 | — |
| 반응물 | Tetrahydrofuran | HCID 8028 | — |
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | 4-Chlorobutane-1-sulphonyl chloride | HCID 74212 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | 4-chloro-N-methylbutane-1-sulfonamide | HCID 10375164 | — |
반응 단계
To a solution of 4-chlorobutane-1-sulfonyl chloride (117 mmol) and triethyl amine (117 mmol) in dichloro methane (250 ml) at 0° C. was added a 2M solution of methyl amine in THF (117 mmol) dropwise. The mixture was allowed to warm to room temperature with stirring overnight. The organic solution was washed with H2O and extracted with CH2Cl2, dried over MgSO4 and filtered. The solution was concentrated. The product was used without further purification.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08497270B2 |
| 출처 데이터셋 | uspto-grants-2013_07 |
| ORD ID | ord-973a1751c9bc4dd493d5322be9346561 |
| 출처 메모 | uspto-grants-2013_07 |