Propargylamine → 9-Nitro-5,6-dihydro-benzo[f]quinoline

반응식

[N+:1]([C:4]1[CH:13]=[C:12]2[C:7]([CH2:8][CH2:9][C:10](=O)[CH2:11]2)=[CH:6][CH:5]=1)([O-:3])=[O:2].[CH2:15]([NH2:18])[C:16]#[CH:17]>>[N+:1]([C:4]1[CH:5]=[CH:6][C:7]2[CH2:8][CH2:9][C:10]3[N:18]=[CH:15][CH:16]=[CH:17][C:11]=3[C:12]=2[CH:13]=1)([O-:3])=[O:2]

참가 물질

반응물 2

HCID 239041Propargylamine

HCID 113214437-Nitro-2-tetralone

생성물 1

HCID 582946079-Nitro-5,6-dihydro-benzo[f]quinoline수율 41%

실험 절차

The title compound is prepared from 7-nitro-2-tetralone and propargylamine following a procedure analogous to that described in Step 1 of Intermediates 1 and 2. Yield: 41% of theory; LC (method 1): tR=2.20 min; Mass spectrum (ESI+): m/z=227 [M+H]+.

출처 및 근거

ORD 기록: ord-3c51b7acceff46d2be648a0cdfd6d98b
출처 데이터셋: uspto-grants-2013_07
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08497281B2

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