1-Methyl-1H-pyrazole-4-boronic acid → HCID 58294593, 화합물

HRID 455369

반응식

HRID 455369 반응식
[F:1][C:2]([F:27])([F:26])[C:3]([N:5]1[CH2:10][CH2:9][CH2:8][C@@H:7]2[C:11]3[CH:12]=[C:13](OS(C(F)(F)F)(=O)=O)[CH:14]=[CH:15][C:16]=3[CH2:17][C@H:6]12)=[O:4].[CH3:28][N:29]1[CH:33]=[C:32](B(O)O)[CH:31]=[N:30]1>>[F:1][C:2]([F:27])([F:26])[C:3]([N:5]1[CH2:10][CH2:9][CH2:8][C@@H:7]2[C:11]3[CH:12]=[C:13]([C:32]4[CH:31]=[N:30][N:29]([CH3:28])[CH:33]=4)[CH:14]=[CH:15][C:16]=3[CH2:17][C@H:6]12)=[O:4]

참가 물질

3

반응물 2

HCID 112635011-Methyl-1H-pyrazole-4-boronic acidHCID 58294405HCID 58294405, 화합물

생성물 1

HCID 58294593HCID 58294593, 화합물수율 32%

실험 절차

The title compound is prepared from trifluoro-methanesulfonic acid cis-1-(2,2,2-trifluoro-acetyl)-2,3,4,4a,9,9a-hexahydro-1H-indeno[2,1-b]pyridin-6-yl ester and 1-methyl-pyrazol-4-yl-boronic acid following a procedure analogous to that described in Step 2 of Intermediates 17 and 18. Yield: 32% of theory; LC (method 1): tR=3.88 min; Mass spectrum (ESI+): m/z=350 [M+H]+.

출처 및 근거

ORD 기록
ord-15400d6a29f54e33aea919d0fe2d6b40
출처 데이터셋
uspto-grants-2013_07
특허 번호
US08497281B2

연결된 노트

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