Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
3-Bromopyridine-2-carboxylic Acid → cis-6-Methoxy-5-methyl-2,3,4,4a,9,9a-hexahydro-1H-indeno[2,1-b]pyridine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 3-Bromopyridine-2-carboxylic Acid | HCID 2050129 | — |
| 반응물 | 2-(3-Methoxy-2-methylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane | HCID 20580667 | — |
| 생성물 | cis-6-Methoxy-5-methyl-2,3,4,4a,9,9a-hexahydro-1H-indeno[2,1-b]pyridine | HCID 67222612 | — |
반응 단계
The title compound is prepared from 3-bromo-pyridine-2-carboxylic acid and 2-(3-methoxy-2-methyl-phenyl)-4,4,5,5-tetramethyl-[1,3,2]dioxaborolane (may be prepared as in WO 2001053268 described) following the synthetic sequence and protocols described for Intermediate 41; since 3-bromo-pyridine-2-carboxylic acid instead of 3-bromo-pyridine-2-carbonitrile is used for the Suzuki-Miyaura coupling (Step 1 of Intermediate 41), hydrolysis of the nitrile (Step 2 of Intermediate 41) is omitted.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08497281B2 |
| 출처 데이터셋 | uspto-grants-2013_07 |
| ORD ID | ord-68c53908be3a4877b8b0e1664dd4ec15 |
| 출처 메모 | uspto-grants-2013_07 |