3-(3,4-Difluoro-phenyl)-N-methyl-3-[4-(1H-pyrazol-4-yl)-phenyl]-propionamide → HCID 11187521, 화합물

HRID 45542

반응식

HRID 45542 반응식
FC1C=C([CH:9]([C:15]2[CH:20]=[CH:19][C:18]([C:21]3[CH:22]=[N:23][NH:24][CH:25]=3)=[CH:17][CH:16]=2)[CH2:10][C:11]([NH:13]C)=[O:12])C=CC=1F.[Cl:26][C:27]1[CH:28]=[C:29]([Mg]Br)[CH:30]=[CH:31][C:32]=1[Cl:33]>>[Cl:26][C:27]1[CH:28]=[C:29]([CH:9]([C:15]2[CH:16]=[CH:17][C:18]([C:21]3[CH:22]=[N:23][NH:24][CH:25]=3)=[CH:19][CH:20]=2)[CH2:10][C:11]([NH2:13])=[O:12])[CH:30]=[CH:31][C:32]=1[Cl:33]

참가 물질

3

반응물 2

HCID 593319553-(3,4-Difluoro-phenyl)-N-methyl-3-[4-(1H-pyrazol-4-yl)-phenyl]-propionamideHCID 178478192HCID 178478192, 화합물

생성물 1

HCID 11187521HCID 11187521, 화합물

실험 절차

By following the procedure described in Example 9A and 9B but substituting 3,4-difluorophenylmagnesium bromide for 3,4-dichlorophenylmagnesium bromide, the title compound was obtained. LC/MS: (PS-A3) Rt 9.82 [M+H]+ 360.14, 362.12. 1H NMR (Me-d3-OD) δ 2.90-3.00 (2H, d), 4.50-4.60 (1H, t), 7.10-7.30 (3H, m), 7.40-7.45 (2H, d), 7.50-7.55 (2H, d), 7.85-8.05 (2H, br s).

출처 및 근거

ORD 기록
ord-7f1a610d772643c597dfb25b80ad06c1
출처 데이터셋
uspto-grants-2013_09
특허 번호
US08541461B2

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