Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1,3-Dibromopropane → Didesmethylsibutramine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1,3-Dibromopropane | HCID 8001 | — |
| 반응물 | 4-Chlorobenzyl cyanide | HCID 241582 | — |
| 생성물 | Didesmethylsibutramine | HCID 134772 | 56.2% |
반응 단계
As described in article (Chinese Journal of Pharmaceuticals, 2001, 32(8): 337-339), p-chlorobenzyl cyanide was condensed with 1,3-dibromopropane, cycled to give cyclobutyl intermediate, and then through Grignard reaction and reduction reaction to give title compound (56.2% yield).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08497305B2 |
| 출처 데이터셋 | uspto-grants-2013_07 |
| ORD ID | ord-f61af2fe89974ddbb36cdcc704faf1e5 |
| 출처 메모 | uspto-grants-2013_07 |