Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Didesmethylsibutramine → Didesmethylsibutramine, (+)-
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Didesmethylsibutramine | HCID 134772 | — |
| 반응물 | D-Tartaric acid | HCID 439655 | — |
| 생성물 | Didesmethylsibutramine, (+)- | HCID 9900576 | — |
반응 단계
As described above, D-(−)-tartaric acid was used to resolute racemic compound II to give another optical isomer (75.2% yield). This optical isomer were treated with alkaline to give free base (R)-1-[1-(4-chlorophenyl)cyclobutyl]-3-methylbutylamine (II-R) (optical purity 99.4%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08497305B2 |
| 출처 데이터셋 | uspto-grants-2013_07 |
| ORD ID | ord-069e4819db2847d492317edf0ab902d5 |
| 출처 메모 | uspto-grants-2013_07 |