3-Bromo-7-(2-fluoropyridin-3-yl)-5',6'-dihydrospiro[chromeno[2,3-b]pyridine-5,4'-[1,3]oxazin]-2'-amine → (S)-3-bromo-7-(2-fluoropyridin-3-yl)-5',6'-dihydrospiro[chromeno[2,3-b]pyridine-5,4'-[1,3]oxazin]-2'-amine

반응식

[Br:1][C:2]1[CH:3]=[C:4]2[C@@:15]3([CH2:20][CH2:19][O:18][C:17]([NH2:21])=[N:16]3)[C:14]3[C:9](=[CH:10][CH:11]=[C:12]([C:22]4[C:23]([F:28])=[N:24][CH:25]=[CH:26][CH:27]=4)[CH:13]=3)[O:8][C:5]2=[N:6][CH:7]=1.[Br:29][C:30]1[CH:31]=[C:32]2[C:43]3([CH2:48][CH2:47][O:46][C:45]([NH2:49])=[N:44]3)[C:42]3[C:37](=[CH:38][CH:39]=[C:40]([C:50]4[C:51]([F:56])=[N:52][CH:53]=[CH:54][CH:55]=4)[CH:41]=3)[O:36][C:33]2=[N:34][CH:35]=1>>[Br:1][C:2]1[CH:3]=[C:4]2[C@:15]3([CH2:20][CH2:19][O:18][C:17]([NH2:21])=[N:16]3)[C:14]3[C:9](=[CH:10][CH:11]=[C:12]([C:22]4[C:23]([F:28])=[N:24][CH:25]=[CH:26][CH:27]=4)[CH:13]=3)[O:8][C:5]2=[N:6][CH:7]=1.[Br:29][C:30]1[CH:31]=[C:32]2[C@@:43]3([CH2:48][CH2:47][O:46][C:45]([NH2:49])=[N:44]3)[C:42]3[C:37](=[CH:38][CH:39]=[C:40]([C:50]4[C:51]([F:56])=[N:52][CH:53]=[CH:54][CH:55]=4)[CH:41]=3)[O:36][C:33]2=[N:34][CH:35]=1