Epichlorohydrin → 1-(2,3-Epoxypropoxy)-4-(2-hydroxyethoxy)benzene

HRID 4557

반응식

HRID 4557 반응식
[OH:1][CH2:2][CH2:3][O:4][C:5]1[CH:10]=[CH:9][C:8]([OH:11])=[CH:7][CH:6]=1.[CH2:12]([CH:14]1[O:16][CH2:15]1)Cl.C(=O)([O-])[O-].[K+].[K+]>>[O:16]1[CH2:15][CH:14]1[CH2:12][O:11][C:8]1[CH:7]=[CH:6][C:5]([O:4][CH2:3][CH2:2][OH:1])=[CH:10][CH:9]=1

참가 물질

4

반응물 3

HCID 7835EpichlorohydrinHCID 11430Potassium CarbonateHCID 98340144-(2-Hydroxyethoxy)phenol

생성물 1

HCID 201513091-(2,3-Epoxypropoxy)-4-(2-hydroxyethoxy)benzene

실험 절차

With stirring, 13 g of crude 4-(2-hydroxyethoxy)phenol, 35 m of epichlorohydrin and 23.5 g of potassium carbonate are heated for 11/2 hours to reflux temperature. The reaction mixture is filtered and the filtrate is concentrated by evaporation under reduced pressure. The residual oil gradually congeals to a crystalline solid, which is recrystallised from isopropanol, affording 1-(2,3-epoxypropoxy)-4-(2-hydroxyethoxy)benzene with a melting point of 65°-67° C. Working up of the mother liquor yields further crystalline product.

후처리

  1. temperatureto reflux temperature
  2. filtrationThe reaction mixture is filtered
  3. concentrationthe filtrate is concentrated by evaporation under reduced pressure
  4. customis recrystallised from isopropanol

출처 및 근거

ORD 기록
ord-74326da63a1b43b7b1f17eec13973a19
출처 데이터셋
uspto-grants-1988_02
특허 번호
US04727067

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