Pipemidic Acid → HCID 45484172, 화합물

HRID 455933

반응식

[CH3:1][CH2:2][N:3]1[C:9]2[N:10]=[C:11]([N:14]3[CH2:19][CH2:18][NH:17][CH2:16][CH2:15]3)[N:12]=[CH:13][C:8]=2[C:6](=[O:7])[C:5]([C:20]([OH:22])=[O:21])=[CH:4]1.[CH3:23][C:24]1[CH:25]=[C:26]([N:31]=[C:32]=[S:33])[CH:27]=[C:28]([CH3:30])[CH:29]=1.C(N(CC)CC)C>>[CH3:23][C:24]1[CH:25]=[C:26]([NH:31][C:32]([N:17]2[CH2:18][CH2:19][N:14]([C:11]3[N:12]=[CH:13][C:8]4[C:6](=[O:7])[C:5]([C:20]([OH:22])=[O:21])=[CH:4][N:3]([CH2:2][CH3:1])[C:9]=4[N:10]=3)[CH2:15][CH2:16]2)=[S:33])[CH:27]=[C:28]([CH3:30])[CH:29]=1

참가 물질

반응물 3

HCID 4831Pipemidic Acid

HCID 8471Triethylamine

HCID 1424063,5-Dimethylphenyl Isothiocyanate

생성물 1

HCID 45484172HCID 45484172, 화합물

실험 절차

Pipemidic acid (45 mg, 0.148 mmol), 3,5-dimethylphenyl isothiocyanate (24 mg, 0.148 mmol) and triethylamine (41 μL, 296 mmol) were used. Purification on silica yielded compound 22 in Table 1, below (41.6 mg, 67%). 1H NMR (300 MHz, CDCl3) δ 9.30 (s, 1H), 8.66 (s, 1H), 7.48 (s, 1H), 6.86-6.75 (m, 3H), 4.33 (q, J=7.10 Hz, 2H), 4.22-3.91 (m, 8H), 2.30 (s, 6H), 1.48 (t, J=7.11 Hz, 3H) ppm.

후처리

customPurification on silica yielded compound 22 in Table 1

출처 및 근거

ORD 기록: ord-1880385935d7483b9b72739c785e365a
출처 데이터셋: uspto-grants-2013_07
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08497371B2

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