Pipemidic Acid → 2-(4-{[(3,5-Dimethylphenyl)amino]carbonothioyl}-1-piperazinyl)-8-ethyl-5-oxo-5,8-dihydropyrido[2,3-d]pyrimidine-6-carboxylic Acid

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Pipemidic acid (45 mg, 0.148 mmol), 3,5-dimethylphenyl isothiocyanate (24 mg, 0.148 mmol) and triethylamine (41 μL, 296 mmol) were used. Purification on silica yielded compound 22 in Table 1, below (41.6 mg, 67%). 1H NMR (300 MHz, CDCl3) δ 9.30 (s, 1H), 8.66 (s, 1H), 7.48 (s, 1H), 6.86-6.75 (m, 3H), 4.33 (q, J=7.10 Hz, 2H), 4.22-3.91 (m, 8H), 2.30 (s, 6H), 1.48 (t, J=7.11 Hz, 3H) ppm.

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