Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1,2-Dibromoethane → 1-(4-Bromophenyl)Cyclopropanecarbonitrile
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1,2-Dibromoethane | HCID 7839 | — |
| 반응물 | Potassium Hydroxide | HCID 14797 | — |
| 반응물 | Benzeneacetonitrile, 4-bromo- | HCID 27914 | — |
| 촉매 | Tetrabutylammonium Bromide | HCID 74236 | — |
| 용매 | Water | HCID 962 | — |
| 용매 | Toluene | HCID 1140 | — |
| 생성물 | 1-(4-Bromophenyl)Cyclopropanecarbonitrile | HCID 2795273 | — |
반응 단계
Potassium hydroxide (14.3 g, 255 mmol) was dissolved in H2O (5 mL) and toluene (40 mL). 4-Bromophenylacetonitrile (5.0 g, 25.5 mmol) and tetrabutylammonium bromide (0.41 g, 1.3 mmol) was added, followed by 1,2-dibromoethane (3.25 mL, 38 mmol) dropwise over 10 minutes. The reaction was stirred at room temperature for 2 hours and then worked-up to give the title compound.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08541587B2 |
| 출처 데이터셋 | uspto-grants-2013_09 |
| ORD ID | ord-e407ecf3ec3f4db980e6cba4bd4ea977 |
| 출처 메모 | uspto-grants-2013_09 |