N,1-Dimethylhydrazine-1-carboxamide → 1-[(E)-1-[3-[(7-fluoroquinolin-6-yl)methyl]imidazo[1,2-b]pyridazin-6-yl]ethylideneamino]-1,3-dimethylurea

HRID 456072

반응식

HRID 456072 반응식
[CH3:1][NH:2][C:3]([N:5]([CH3:7])[NH2:6])=[O:4].[F:8][C:9]1[CH:18]=[C:17]2[C:12]([CH:13]=[CH:14][CH:15]=[N:16]2)=[CH:11][C:10]=1[CH2:19][C:20]1[N:24]2[N:25]=[C:26]([C:29](=O)[CH3:30])[CH:27]=[CH:28][C:23]2=[N:22][CH:21]=1>>[F:8][C:9]1[CH:18]=[C:17]2[C:12]([CH:13]=[CH:14][CH:15]=[N:16]2)=[CH:11][C:10]=1[CH2:19][C:20]1[N:24]2[N:25]=[C:26](/[C:29](=[N:6]/[N:5]([CH3:7])[C:3]([NH:2][CH3:1])=[O:4])/[CH3:30])[CH:27]=[CH:28][C:23]2=[N:22][CH:21]=1

참가 물질

3

반응물 2

HCID 304021N,1-Dimethylhydrazine-1-carboxamideHCID 581905991-[3-(7-Fluoro-quinolin-6-ylmethyl)-imidazo[1,2-b]pyridazin-6-yl]ethanone

생성물 1

HCID 716998731-[(E)-1-[3-[(7-fluoroquinolin-6-yl)methyl]imidazo[1,2-b]pyridazin-6-yl]ethylideneamino]-1,3-dimethylurea수율 21%

실험 절차

The title compound was prepared from N,1-dimethylhydrazine carboxamide and 1-[3-(7-fluoro-quinolin-6-ylmethyl)-imidazo[1,2-b]pyridazin-6-yl]-ethanone in analogy to the synthesis of example 1 in 21% yield. 1H-NMR (400 MHz, DMSO-d6) δ ppm 8.86 (dd, 1H), 8.31 (d, 1H), 8.06 (m, 2H), 7.97 (d, 1H), 7.77 (d, 1H), 7.73 (s, 1H), 7.47 (q, 1H), 6.90 (q, 1H), 4.59 (s, 2H), 3.19 (s, 3H), 2.68 (d, 3H), 2.37 (s, 3H). LCMS (method B): [MH]+=406, tR=2.27 min.

출처 및 근거

ORD 기록
ord-209bec646ed747fba0c39c0788c11f52
출처 데이터셋
uspto-grants-2013_07
특허 번호
US08497368B2

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