반응식
[CH2:1]([NH:8][C:9]([NH:11][NH2:12])=[S:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[F:13][C:14]1[CH:23]=[C:22]2[C:17]([CH:18]=[CH:19][CH:20]=[N:21]2)=[CH:16][C:15]=1[CH2:24][C:25]1[N:29]2[N:30]=[C:31]([C:34](=O)[CH3:35])[CH:32]=[CH:33][C:28]2=[N:27][CH:26]=1>>[CH2:1]([NH:8][C:9]([NH:11]/[N:12]=[C:34](/[C:31]1[CH:32]=[CH:33][C:28]2[N:29]([C:25]([CH2:24][C:15]3[CH:16]=[C:17]4[C:22](=[CH:23][C:14]=3[F:13])[N:21]=[CH:20][CH:19]=[CH:18]4)=[CH:26][N:27]=2)[N:30]=1)\[CH3:35])=[S:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1참가 물질
3
실험 절차
The title compound was prepared from N-benzylhydrazine carbothioamide and 1-[3-(7-fluoro-quinolin-6-ylmethyl)-imidazo[1,2-b]pyridazin-6-yl]-ethanone in analogy to the synthesis of example 1 in 80% yield. 1H-NMR (400 MHz, DMSO-d6) δ ppm 10.58 (s, 1H), 9.30 (t, 1H), 8.86 (dd, 1H), 8.30 (m, 2H), 8.05 (d, 1H), 7.95 (d, 1H), 7.77 (d, 1H), 7.69 (s, 1H), 7.47 (q, 1H), 7.32 (m, 4H), 7.23 (m, 1H), 4.89 (d, 2H), 4.58 (s, 2H), 2.39 (s, 3H). LCMS (method C): [MH]+=484, tR=4.18 min.
출처 및 근거
- ORD 기록
- ord-70e0ac505cc44e77ab5dc6d678e62eaa
- 출처 데이터셋
- uspto-grants-2013_07
- 특허 번호
- US08497368B2
연결된 노트
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