반응식
[N:1]1[C:10]2[C:5](=[CH:6][C:7]([CH2:11][N:12]3[C:16]4=[N:17][C:18]([C:21](=O)[CH3:22])=[CH:19][N:20]=[C:15]4[N:14]=[N:13]3)=[CH:8][CH:9]=2)[CH:4]=[CH:3][CH:2]=1.[O:24]1[CH2:29][CH2:28][N:27]([CH2:30][C:31]([NH:33][NH2:34])=[O:32])[CH2:26][CH2:25]1>>[O:24]1[CH2:25][CH2:26][N:27]([CH2:30][C:31]([NH:33]/[N:34]=[C:21](/[C:18]2[N:17]=[C:16]3[N:12]([CH2:11][C:7]4[CH:6]=[C:5]5[C:10](=[CH:9][CH:8]=4)[N:1]=[CH:2][CH:3]=[CH:4]5)[N:13]=[N:14][C:15]3=[N:20][CH:19]=2)\[CH3:22])=[O:32])[CH2:28][CH2:29]1참가 물질
3
실험 절차
The title compound was prepared in analogy to the synthesis of example 52 from 1-(1-(quinolin-6-ylmethyl)-1H-[1,2,3]triazolo[4,5-b]pyrazin-6-yl)ethanone and 2-morpholinoaceto-hydrazide. The title compound was obtained as light yellow solid. 1H-NMR (400 MHz, DMSO-d6) δ ppm 9.45 (d, 1H), 8.90 (d, 1H), 8.36 (d, 1H), 8.01 (m, 2H), 7.83 (d, 1H), 7.53 (dd, 1H), 6.20 (s, 2H), 3.65 (d, 4H), 3.26 (s, 2H), 2.57 (d, 4H), 2.41 (s, 3H). LCMS (method B): [MH]+=446.2, tR=1.37 min.
출처 및 근거
- ORD 기록
- ord-c33e89b51c774a209623ec5889d2681f
- 출처 데이터셋
- uspto-grants-2013_07
- 특허 번호
- US08497368B2
연결된 노트
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