6-[6-(1-Ethoxy-vinyl)[1,2,3]triazolo[4,5-b]pyrazin-1-ylmethyl]-quinoline → 6-(1-(6-(1-Ethoxyvinyl)-1H-[1,2,3]triazolo[4,5-b]pyrazin-1-yl)ethyl)-7-fluoroquinoline

HRID 456143

반응식

HRID 456143 반응식
[CH2:1]([O:3][C:4](C1N=C2N(CC3C=C4C(=CC=3)N=CC=C4)N=NC2=NC=1)=[CH2:5])[CH3:2].Br[C:27]1[N:32]=[C:31]2[N:33]([CH:36]([C:38]3[CH:39]=[C:40]4[C:45](=[CH:46][C:47]=3[F:48])[N:44]=[CH:43][CH:42]=[CH:41]4)[CH3:37])[N:34]=[N:35][C:30]2=[N:29][CH:28]=1>>[CH2:4]([O:3][C:1]([C:27]1[N:32]=[C:31]2[N:33]([CH:36]([C:38]3[CH:39]=[C:40]4[C:45](=[CH:46][C:47]=3[F:48])[N:44]=[CH:43][CH:42]=[CH:41]4)[CH3:37])[N:34]=[N:35][C:30]2=[N:29][CH:28]=1)=[CH2:2])[CH3:5]

참가 물질

3

반응물 2

HCID 248519576-[6-(1-Ethoxy-vinyl)[1,2,3]triazolo[4,5-b]pyrazin-1-ylmethyl]-quinolineHCID 866660826-(1-(6-Bromo-1H-[1,2,3]triazolo[4,5-b]pyrazin-1-yl)ethyl)-7-fluoroquinoline

생성물 1

HCID 669272076-(1-(6-(1-Ethoxyvinyl)-1H-[1,2,3]triazolo[4,5-b]pyrazin-1-yl)ethyl)-7-fluoroquinoline

실험 절차

The title compound was prepared in analogy to the synthesis of compound 52.3 from 6-(1-(6-bromo-1H-[1,2,3]triazolo[4,5-b]pyrazin-1-yl)ethyl)-7-fluoroquinoline. 1H-NMR (400 MHz, CDCl3) δ ppm 9.17 (9.17 (s, 1H), 8.90 (m, 1H), 8.10 (d, 1H), 7.89 (d, 1H), 7.78 (d, 1H), 7.39 (dd, 1H), 6.82 (q, 1H), 5.56 (d, 1H), 4.56 (d, 1H), 4.04 (q, 2H), 2.30 (d, 3H), 1.48 (t, 3H). LCMS (method B): [MH]+=365, tR=2.55 min.

출처 및 근거

ORD 기록
ord-d37acd31ff2849e687719bb64c565e21
출처 데이터셋
uspto-grants-2013_07
특허 번호
US08497368B2

연결된 노트

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