1-(1-(Quinolin-6-ylmethyl)-1H-[1,2,3]triazolo[4,5-b]pyrazin-6-yl)ethanone → 1-(1-(1-(7-Fluoroquinolin-6-yl)ethyl)-1H-[1,2,3]triazolo[4,5-b]pyrazin-6-yl)ethanone
반응식
N1C2C(=CC(CN3C4=NC(C(=O)C)=CN=C4N=N3)=CC=2)C=CC=1.C([O:26][C:27]([C:29]1[N:34]=[C:33]2[N:35]([CH:38]([C:40]3[CH:41]=[C:42]4[C:47](=[CH:48][C:49]=3[F:50])[N:46]=[CH:45][CH:44]=[CH:43]4)[CH3:39])[N:36]=[N:37][C:32]2=[N:31][CH:30]=1)=[CH2:28])C>>[F:50][C:49]1[CH:48]=[C:47]2[C:42]([CH:43]=[CH:44][CH:45]=[N:46]2)=[CH:41][C:40]=1[CH:38]([N:35]1[C:33]2=[N:34][C:29]([C:27](=[O:26])[CH3:28])=[CH:30][N:31]=[C:32]2[N:37]=[N:36]1)[CH3:39]참가 물질
3
실험 절차
The title compound was prepared in analogy to the synthesis of compound of 52.4 from 6-(1-(6-(1-ethoxyvinyl)-1H-[1,2,3]triazolo[4,5-b]pyrazin-1-yl)ethyl)-7-fluoroquinoline. 1H-NMR (400 MHz, CDCl3) δ ppm 9.44 (s, 1H), 8.93 (m, 1H), 8.13 (d, 1H), 7.94 (s, 1H) 7.79 (d, 1H), 7.41 (dd, 1H), 6.88 (q, 1H), 2.76 (s, 3H), 2.37 (d, 3H). LCMS (method B): [MH]+=337, tR=2.21 min.
출처 및 근거
- ORD 기록
- ord-af339235733e40798c032325a933c498
- 출처 데이터셋
- uspto-grants-2013_07
- 특허 번호
- US08497368B2
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