Potassium Carbonate → [4-Fluoro-2'-((4S,5R)-4-methyl-2-oxo-5-phenyl-oxazolidin-3-ylmethyl)-4'-trifluoromethyl-biphenyl-3-yl]-acetic acid

참여 물질

역할	이름	HCID	투입량
반응물	Potassium Carbonate	HCID 11430	—
반응물	2-(5-Bromo-2-fluorophenyl)acetic acid	HCID 3584690	—
반응물	(4S,5R)-4-Methyl-5-phenyl-3-[2-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-5-trifluoromethyl-benzyl]-oxazolidin-2-one	HCID 66890959	—
촉매	HCID 178418397	HCID 178418397	—
용매	Water 1,2-dimethoxyethane	HCID 18180031	—
생성물	[4-Fluoro-2'-((4S,5R)-4-methyl-2-oxo-5-phenyl-oxazolidin-3-ylmethyl)-4'-trifluoromethyl-biphenyl-3-yl]-acetic acid	HCID 44205721	—

반응 조건

온도	90 °C

반응 단계

(4S,5R)-4-Methyl-5-phenyl-3-[2-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-5-trifluoromethyl-benzyl]-oxazolidin-2-one (0.080 g, 0.17 mmol), 5-bromo-2-fluorophenylacetic acid (0.061 g, 0.26 mmol), potassium carbonate (0.084 g, 0.61 mmol), and tetrakis(triphenylphosphine)palladium (0) (0.021 g, 0.02 mmol) were combined in DME:H2O (2:1; 3 mL), and the mixture was purged with N2 for 5 minutes. The reaction was stirred under N2 at 90° C. overnight. After work-up with EtOAc and brine, the crude material was purified by silica gel chromatography (0-5% MeOH in CH2Cl2) to give the title compound. M+H is 488.

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US08497381B2
출처 데이터셋	uspto-grants-2013_07
ORD ID	ord-fd4b7ed0d84443efae10e23df2562847
출처 메모	uspto-grants-2013_07