5-Bromo-2-methoxyphenylacetic acid → [4-Methoxy-2'-((4S,5R)-4-methyl-2-oxo-5-phenyl-oxazolidin-3-ylmethyl)-4'-trifluoromethyl-biphenyl-3-yl]-acetic acid

HRID 456207

반응식

HRID 456207 반응식
[CH3:1][C@H:2]1[C@@H:6]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)[O:5][C:4](=[O:13])[N:3]1[CH2:14][C:15]1[CH:20]=[C:19]([C:21]([F:24])([F:23])[F:22])[CH:18]=[CH:17][C:16]=1B1OC(C)(C)C(C)(C)O1.Br[C:35]1[CH:36]=[CH:37][C:38]([O:45][CH3:46])=[C:39]([CH2:41][C:42]([OH:44])=[O:43])[CH:40]=1>>[CH3:46][O:45][C:38]1[CH:37]=[CH:36][C:35]([C:16]2[CH:17]=[CH:18][C:19]([C:21]([F:22])([F:24])[F:23])=[CH:20][C:15]=2[CH2:14][N:3]2[C@@H:2]([CH3:1])[C@@H:6]([C:7]3[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=3)[O:5][C:4]2=[O:13])=[CH:40][C:39]=1[CH2:41][C:42]([OH:44])=[O:43]

참가 물질

3

반응물 2

HCID 5553065-Bromo-2-methoxyphenylacetic acidHCID 66890959HCID 66890959, 화합물

생성물 1

HCID 44205722[4-Methoxy-2'-((4S,5R)-4-methyl-2-oxo-5-phenyl-oxazolidin-3-ylmethyl)-4'-trifluoromethyl-biphenyl-3-yl]-acetic acid

실험 절차

Prepared according to the procedure described in Example 7, Step 2, using the following starting materials: (4S,5R)-4-methyl-5-phenyl-3-[2-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-5-trifluoromethyl-benzyl]-oxazolidin-2-one and 5-bromo-2-methoxyphenylacetic acid. M+H is 500.

후처리

  1. customPrepared

출처 및 근거

ORD 기록
ord-fd689a3f5e57491ab3a99985a2eb3ab5
출처 데이터셋
uspto-grants-2013_07
특허 번호
US08497381B2

연결된 노트

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