Acetate → 4-(4-(2-Hydroxyphenyl)thiophenyl)butyric acid

HRID 456352

반응식

HRID 456352 반응식
I[C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][CH2:10][C:11]([OH:13])=[O:12])=[CH:4][CH:3]=1.C(=O)([O-])[O-].[K+].[K+].[OH:20][C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][C:22]=1[SH:27].C([O-])(=O)C>CN(C)C=O>[OH:20][C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][C:22]=1[S:27][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][CH2:10][C:11]([OH:13])=[O:12])=[CH:4][CH:3]=1

참가 물질

6

반응물 4

HCID 175AcetateHCID 11430Potassium CarbonateHCID 70718Phenol, o-mercapto-(6CI,7CI,8CI)HCID 46454274-(p-Iodophenyl)butyric acid

생성물 1

HCID 684943804-(4-(2-Hydroxyphenyl)thiophenyl)butyric acid

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

A solution of 4-(4-iodophenyl)butyric acid (0.86M) and dimethylformamide was treated with 2 eq of potassium carbonate, 1.5 eq of 2-hydroxythiophenol and a catalytic amount of cuperic acetate (0.01 eq). The reaction mixture was refluxed for 18 hr, cooled to 25 C., acidified with aqueous acid and extracted with ethyl acetate. The organic phase was concentrated. The residue was purified by flash chromatography using ethyl acetate/hexane as eluant to give 4-(4-(2-hydroxyphenyl)thiophenyl)butyric acid.

후처리

  1. temperatureThe reaction mixture was refluxed for 18 hr
  2. temperaturecooled to 25 C
  3. extractionextracted with ethyl acetate
  4. concentrationThe organic phase was concentrated
  5. customThe residue was purified by flash chromatography

출처 및 근거

ORD 기록
ord-04b72043e96b43279518ad408494aeec
출처 데이터셋
uspto-grants-2007_03
특허 번호
US07186414B2

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