2-Oxoimidazolidine-1-carbonyl chloride → cis-4-(3-Chloro-4-methoxy-phenyl)-2-{1-[1-(2-oxo-imidazolidin-1-yl)-methanoyl]-piperidin-4-yl}-4a,5,8,8a-tetrahydro-2H-phthalazin-1-one

HRID 456385

반응식

HRID 456385 반응식
[O:1]=[C:2]1[NH:6][CH2:5][CH2:4][N:3]1[C:7](Cl)=[O:8].[Cl:10][C:11]1[CH:12]=[C:13]([C:19]2[C@H:28]3[C@H:23]([CH2:24][CH:25]=[CH:26][CH2:27]3)[C:22](=[O:29])[N:21]([CH:30]3[CH2:35][CH2:34][N:33](C(N4CCOCC4)=O)[CH2:32][CH2:31]3)[N:20]=2)[CH:14]=[CH:15][C:16]=1[O:17][CH3:18]>>[Cl:10][C:11]1[CH:12]=[C:13]([C:19]2[C@H:28]3[C@H:23]([CH2:24][CH:25]=[CH:26][CH2:27]3)[C:22](=[O:29])[N:21]([CH:30]3[CH2:35][CH2:34][N:33]([C:7]([N:3]4[CH2:4][CH2:5][NH:6][C:2]4=[O:1])=[O:8])[CH2:32][CH2:31]3)[N:20]=2)[CH:14]=[CH:15][C:16]=1[O:17][CH3:18]

참가 물질

3

반응물 2

HCID 832412-Oxoimidazolidine-1-carbonyl chlorideHCID 69490073(cis)-4-(3-Chloro-4-methoxy-phenyl)-2-[1-(1-morpholin-4-yl-methanoyl)-piperidin-4-yl]-4a,5,8,8a-tetrahydro-2H-phthalazin-1-one

생성물 1

HCID 69487067cis-4-(3-Chloro-4-methoxy-phenyl)-2-{1-[1-(2-oxo-imidazolidin-1-yl)-methanoyl]-piperidin-4-yl}-4a,5,8,8a-tetrahydro-2H-phthalazin-1-one

실험 절차

Prepared from intermediate product A1 and 2-oxo-imidazolidine-1-carbonyl chloride as described for compound 1. M. p. 216–218° C.

출처 및 근거

ORD 기록
ord-ccb0ea35762f4351893693de985e55d3
출처 데이터셋
uspto-grants-2007_03
특허 번호
US07186710B2

연결된 노트

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