Cyclopropylamine → N-cyclopropyl-2-hydroxybenzamide

HRID 456397노트

반응식

HRID 456397 반응식
C[O:2][C:3]1[C:4](=[CH:8][CH:9]=[CH:10][CH:11]=1)[C:5]([O-:7])=O.[CH:12]1([NH2:15])[CH2:14][CH2:13]1>C1(C)C=CC=CC=1>[CH:12]1([NH:15][C:5](=[O:7])[C:4]2[CH:8]=[CH:9][CH:10]=[CH:11][C:3]=2[OH:2])[CH2:14][CH2:13]1

참가 물질

4

반응물 2

HCID 69828Cyclopropylamine2회HCID 69502182-Methoxybenzoate

생성물 1

HCID 822771N-cyclopropyl-2-hydroxybenzamide수율 53.3%

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

A mixture of methylsalicylate (4.36 g, 28.69 mmol) and cyclopropylamine (1.64 g, 28.69 mmol) was heated at 80–100° C. for 3 h. An additional 0.5 equivalent of cyclopropylamine was added and the reaction mixture was kept at 70° C. for overnight. The reaction mixture was co-evaporated with toluene and the residue was purified by silica gel flash chromatography to give the subtitle compound (2.71 g).

후처리

  1. temperaturewas heated at 80–100° C. for 3 h
  2. customthe residue was purified by silica gel flash chromatography

출처 및 근거

ORD 기록
ord-740826eff3a74334a73f1cecb41741a3
출처 데이터셋
uspto-grants-2007_03
특허 번호
US07186718B2

반응 노트

불러오는 중…