Acetyl chloride → 1-(4-Hydroxypiperidin-1-yl)ethan-1-one

HRID 456446노트

반응식

HRID 456446 반응식
[OH:1][CH:2]1[CH2:7][CH2:6][NH:5][CH2:4][CH2:3]1.C(N(CC)CC)C.[C:15](Cl)(=[O:17])[CH3:16]>C(Cl)Cl>[OH:1][CH:2]1[CH2:7][CH2:6][N:5]([C:15](=[O:17])[CH3:16])[CH2:4][CH2:3]1

참가 물질

5

반응물 3

HCID 6367Acetyl chlorideHCID 8471TriethylamineHCID 79341Piperidin-4-ol

생성물 1

HCID 107492911-(4-Hydroxypiperidin-1-yl)ethan-1-one수율 80%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

반응 조건

온도
-78 °C

실험 절차

4-hydroxypiperidine (0.534 g, 5.3 mmol) was dissolved in methylene chloride (50 mL). The solution was cooled to −78° C. and triethylamine (1.10 mL, 7.95 mmol) was added. Acetyl chloride (0.33 mL, 4.77 mmol) was added dropwise to the mixture. The mixture was warmed to r.t., concentrated under reduced pressure and purified using silica gel chromatography (50% ethyl acetate in hexanes) to give the title compound (0.540 g, 80%) as an oil.

후처리

  1. temperatureThe mixture was warmed to r.t.
  2. concentrationconcentrated under reduced pressure
  3. custompurified

출처 및 근거

ORD 기록
ord-933c51307fc34f10a9c99671f521d0db
출처 데이터셋
uspto-grants-2007_03
특허 번호
US07186715B2

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