Methylcyclohexane → (1S,2S)-2-methoxycarbonylcyclopropanecarboxylic acid
반응식
[CH3:1][O:2][C:3]([C@@H:5]1[CH2:7][C@H:6]1[C:8]([OH:10])=[O:9])=[O:4].COC1C=CC2N=CC=C([C@@H](O)[C@H]3N4C[C@H](C=C)[C@@H](CC4)C3)C=2C=1.CC1CCCCC1>CC(C)=O>[CH3:1][O:2][C:3]([C@H:5]1[CH2:7][C@@H:6]1[C:8]([OH:10])=[O:9])=[O:4]참가 물질
5
실험 절차
Add trans-cyclopropane-1,2-dicarboxylic acid monomethyl ester, Example 3a, (19.46 g) in acetone to quinine (43.8 g) in one portion. Heat the reaction to reflux, and then add methylcyclohexane (150 mL). After crystallization (5 times) from acetone/methylcyclohexane, collect 6.2 g of the diastereomeric salt (αD:+173, c:7.3 CHCl3)
후처리
- temperatureHeat
- customthe reaction
- temperatureto reflux
- customAfter crystallization (5 times) from acetone/methylcyclohexane
- customcollect 6.2 g of the diastereomeric salt (αD:+173, c:7.3 CHCl3)
출처 및 근거
- ORD 기록
- ord-cab5625791944481b134ae2d9921a211
- 출처 데이터셋
- uspto-grants-2007_03
- 특허 번호
- US07186724B2
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