p-Bromoacetophenone → 4-Bromophenacyl bromide

HRID 45652

반응식

HRID 45652 반응식
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=[O:10])[CH3:9])=[CH:4][CH:3]=1.[Br:11]Br>C(O)(=O)C>[Br:11][CH2:9][C:8]([C:5]1[CH:6]=[CH:7][C:2]([Br:1])=[CH:3][CH:4]=1)=[O:10]

참가 물질

4

반응물 2

HCID 7466p-BromoacetophenoneHCID 24408Bromine

생성물 1

HCID 74544-Bromophenacyl bromide수율 67%

시약·촉매·용매 1

HCID 176Acetic Acid용매2회

반응 조건

온도
60 °C

실험 절차

Into a 250-mL 3-necked round-bottom flask, was placed a solution of 1-(4-bromophenyl)ethanone (10.0 g, 50.25 mmol, 1.00 equiv) in acetic acid (50 mL). This was followed by the addition of a solution of bromine (8.2 g, 1.05 equiv) in acetic acid (50 mL) dropwise with stirring at 60° C. over 90 min. The resulting solution was stirred for 3 h at 60° C. The resulting mixture was concentrated under vacuum. The crude product was re-crystallized from petroleum ether/ethyl acetate in the ratio of 7:1. This resulted in 9.3 g (67%) of the title compound as a yellow solid.

후처리

  1. customInto a 250-mL 3-necked round-bottom flask, was placed
  2. stirringThe resulting solution was stirred for 3 h at 60° C
  3. concentrationThe resulting mixture was concentrated under vacuum
  4. customThe crude product was re-crystallized from petroleum ether/ethyl acetate in the ratio of 7:1

출처 및 근거

ORD 기록
ord-531419fd15e1467baf639234e50ceeb9
출처 데이터셋
uspto-grants-2013_09
특허 번호
US08541448B2

연결된 노트

불러오는 중…