Propylamine hydrochloride → 6-Methoxy-1,5-naphthyridin-4-amine

HRID 456579노트

반응식

HRID 456579 반응식
[CH3:1][O:2][C:3]1[N:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[N:9]=[CH:8][CH:7]=[C:6]2OS(C(F)(F)F)(=O)=O.Cl.C([NH2:25])CC>N1C=CC=CC=1>[CH3:1][O:2][C:3]1[N:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[N:9]=[CH:8][CH:7]=[C:6]2[NH2:25]

참가 물질

4

반응물 2

HCID 11165Propylamine hydrochlorideHCID 112552656-Methoxy-1,5-naphthyridin-4-yl trifluoromethanesulfonate

생성물 1

HCID 114352366-Methoxy-1,5-naphthyridin-4-amine수율 91.4%

시약·촉매·용매 1

HCID 1049Pyridine용매

실험 절차

A mixture of triflate (b) (25 g, 81.2 mmol) and propylamine hydrochloride (47 g, 487 mmol) in pyridine (300 ml) was heated to reflux overnight. The mixture was evaporated to dryness, dissolved in 0.5M aqueous hydrochloric acid (400 ml) and extracted three times with dichloromethane. The aqueous phase was then basified with 40% aqueous sodium hydroxide solution and extracted twice with dichloromethane. Drying and evaporation afforded a buff coloured solid (13.0 g, 90%).

후처리

  1. temperaturewas heated
  2. temperatureto reflux overnight
  3. customThe mixture was evaporated to dryness
  4. dissolutiondissolved in 0.5M aqueous hydrochloric acid (400 ml)
  5. extractionextracted three times with dichloromethane
  6. extractionextracted twice with dichloromethane
  7. customDrying
  8. customevaporation

출처 및 근거

ORD 기록
ord-3162b2c3d3954e30bf5f676d9b6d0ff6
출처 데이터셋
uspto-grants-2007_03
특허 번호
US07186730B2

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