Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4-(6-Methoxy-[1,5]naphthyridin-4-ylcarbamoyl)-piperidine-1-carboxylic acid benzyl ester → Piperidine-4-carboxylic acid (6-methoxy-[1,5]naphthyridin-4-yl)-amide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4-(6-Methoxy-[1,5]naphthyridin-4-ylcarbamoyl)-piperidine-1-carboxylic acid benzyl ester | HCID 11247158 | — |
| 촉매 | Palladiumcarbon | HCID 14818447 | — |
| 용매 | Ethanol ethylacetate | HCID 21584252 | — |
| 생성물 | Piperidine-4-carboxylic acid (6-methoxy-[1,5]naphthyridin-4-yl)-amide | HCID 11231497 | 59% |
반응 단계
A solution of (e) (6.0 g, 14.3 mmol) in ethanol/ethyl acetate (150 ml/150 ml) was hydrogenated over 10% Pd/charcoal (5 g) for 1.5 hours. Filtration, washing with ethanol (400 ml) and evaporation of the filtrate gave a white solid (2.4 g, 59%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07186730B2 |
| 출처 데이터셋 | uspto-grants-2007_03 |
| ORD ID | ord-62de4b780e9d4801979ff0c701b6f06c |
| 출처 메모 | uspto-grants-2007_03 |