Triethylamine → 3,4-Methylenedioxyphenethyl mesylate

HRID 456587노트

반응식

HRID 456587 반응식
[O:1]1[C:5]2[CH:6]=[CH:7][C:8]([CH2:10][CH2:11][OH:12])=[CH:9][C:4]=2[O:3][CH2:2]1.C(N(CC)CC)C.[CH3:20][S:21](Cl)(=[O:23])=[O:22]>ClCCl>[O:1]1[C:5]2[CH:6]=[CH:7][C:8]([CH2:10][CH2:11][O:12][S:21]([CH3:20])(=[O:23])=[O:22])=[CH:9][C:4]=2[O:3][CH2:2]1

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 31297Methanesulfonyl chlorideHCID 27598462-(1,3-Dioxaindan-5-yl)ethan-1-ol

생성물 1

HCID 186255853,4-Methylenedioxyphenethyl mesylate수율 100.5%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

A solution of alcohol (a) (1.90 g, 11 mmol) in dichloromethane (25 ml) was treated at 0° C. with triethylamine (1.9 ml, 13.7 mmol) and methanesulfonyl chloride (1.1 ml, 13.7 mmol). After 1.5 hours at room temperature the mixture was partitioned between dichloromethane and water. The organic extract was dried and evaporated to give a yellow oil (2.7 g, 96%).

후처리

  1. customAfter 1.5 hours at room temperature the mixture was partitioned between dichloromethane and water
  2. extractionThe organic extract
  3. customwas dried
  4. customevaporated

출처 및 근거

ORD 기록
ord-411bf821d8784d468f227ada430abb2a
출처 데이터셋
uspto-grants-2007_03
특허 번호
US07186730B2

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