Acrylonitrile → Ethyl 1-(2-cyanoethyl)piperidine-4-carboxylate

HRID 456590노트

반응식

HRID 456590 반응식
C([N:3]1CC[CH:6](C(O)=O)[CH2:5][CH2:4]1)C.[CH2:12]([O:14][C:15]([CH:17]1[CH2:22][CH2:21][NH:20][CH2:19][CH2:18]1)=[O:16])[CH3:13].C(#N)C=C>C(O)(C)C>[CH2:12]([O:14][C:15]([CH:17]1[CH2:22][CH2:21][N:20]([CH2:6][CH2:5][C:4]#[N:3])[CH2:19][CH2:18]1)=[O:16])[CH3:13]

참가 물질

4

반응물 2

HCID 7855AcrylonitrileHCID 86594498Piperidine-4-carboxylic acid ethyl ester (ethylisonipecotate)

생성물 1

HCID 43084552Ethyl 1-(2-cyanoethyl)piperidine-4-carboxylate수율 101.5%

시약·촉매·용매 1

HCID 3776Isopropanol용매

실험 절차

A solution of piperidine-4-carboxylic acid ethyl ester (ethylisonipecotate) (4.7 g, 30 mmol), acrylonitrile (1.7 g, 31 mmol) in isopropyl alcohol (30 ml) was stirred at room temperature for 15 hours, then evaporated to dryness to afford 1-(2-cyano-ethyl)-piperidine-4-carboxylic acid ethyl ester as an oil (6.4 g, 100%).

후처리

  1. customevaporated to dryness

출처 및 근거

ORD 기록
ord-7524ec68f1c04433b6e1f6aa8924b0bb
출처 데이터셋
uspto-grants-2007_03
특허 번호
US07186730B2

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