Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Tetrahydrofuran → 5-(2-Hydroxy-ethyl)-3H-benzoxazol-2-one
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Tetrahydrofuran | HCID 8028 | — |
| 반응물 | Sodium Hydroxide | HCID 14798 | — |
| 반응물 | Sulfuric acid magnesium salt (1:1) | HCID 24083 | — |
| 반응물 | Hydride | HCID 166653 | — |
| 반응물 | Aluminium lithium hydride | HCID 21226445 | — |
| 반응물 | 5-Cyanomethylbenz-2,1,3-thiadiazole | HCID 69522445 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | 5-(2-Hydroxy-ethyl)-3H-benzoxazol-2-one | HCID 17981229 | 65% |
반응 단계
Ester (a) (0.95 g, 4.29 mmol) was added portionwise to a cold solution (0° C.) of lithium aluminium hydride (0.206 g, 4.7 mmol) in tetrahydrofuran (20 ml). The mixture was then stirred 1.5 hours at room temperature and cooled again. The excess of hydride was hydrolysed by careful addition of water (0.2 ml), 5N aqueous sodium hydroxide solution (0.2 ml) and finally water (0.6 ml). Magnesium sulfate was added and the mixture was filtered. The filtrate was concentrated to dryness to give the product (0.5 g, 65%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07186730B2 |
| 출처 데이터셋 | uspto-grants-2007_03 |
| ORD ID | ord-b2a5bce6931b4469875ced99a3d86bcb |
| 출처 메모 | uspto-grants-2007_03 |