Methylamine → N-Methyl-1H-pyrrole-2-carboxamide

HRID 456658노트

반응식

HRID 456658 반응식
[NH:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6]([OH:8])=O.C(Cl)(=O)C(Cl)=O.[CH3:15][NH2:16]>C(Cl)Cl.CN(C=O)C.N1C=CC=C1C(Cl)=O.C(OCC)(=O)C>[CH3:15][NH:16][C:6]([C:2]1[NH:1][CH:5]=[CH:4][CH:3]=1)=[O:8]

참가 물질

8

반응물 3

HCID 6329MethylamineHCID 12473Pyrrole-2-Carboxylic AcidHCID 65578Oxalyl chloride

생성물 1

HCID 23273389N-Methyl-1H-pyrrole-2-carboxamide

시약·촉매·용매 4

HCID 6228Dimethylformamide촉매HCID 6344Dichloromethane용매HCID 8857Ethyl Acetate용매HCID 224558Pyrrole-2-carbonyl chloride용매

실험 절차

To a solution of 1H-pyrrole-2-carboxylic acid (1 g, 9 mmol) (Aldrich, Milwaukee, Wis.) in DCM (15 mL) was added oxalyl chloride (1.1 mL) and DMF (3 drops). The mixture was stirred at room temperature resulting in 1H-pyrrole-2-carbonyl chloride. Methylamine (30 mmol) was then added to the acid chloride and the mixture was stirred at room temperature. The reaction was diluted with ethyl acetate, washed with brine (2×), NaHCO3, dried and concentrated to give 1H-pyrrole-2-carboxylic acid methylamide.

후처리

  1. stirringthe mixture was stirred at room temperature
  2. washwashed with brine (2×), NaHCO3
  3. customdried
  4. concentrationconcentrated

출처 및 근거

ORD 기록
ord-b651e65a5daa42c48177d12dc97e29c8
출처 데이터셋
uspto-grants-2007_03
특허 번호
US07186716B2

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